Valproate for acute mania

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Valproate in Acute Mania - a Controlled Study

A controlled blind study was carried out to establish the efficacy of Sodium Valproate as the first line of treatment in Acute Mania. Patients were studied over a period of 4 weeks. Using randomised table patients were assigned to either lithium or valproate. Decrease in the psychopathology was evident within 2-3 weeks. Valproate was found to be as effective as Lithium in controlling the manic ...

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valproate-risperidone versus valproate-lithium combination in acute mania

background: we evaluated the efficacy of valproate plus risperidone versus valproate plus lithium combination in the treatment of acute mania. methods: in 2-week, randomized, double-blind, parallel group study, 46 acute manic patients according to dsm-iv criteria were randomly assigned to receive combination of valproate 20 mg/ kg/day plus risperidone 2-4 mg/day (n=23) or lithium600-1200 mg/day...

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comparision of the efficacy of two combinations sodium valproate with lithium & sodium valproate with olanzapine in treatment of acute mania

introduction: acute mania is a psychiatric emergency state that often requires rapid management. there are many different therapeutic protocols for this emergent situation. one of them is combination of moodstabilizers and antipsychotics. olanzapine which is now available in our country can be used for this purpose. methods and materials: in this study, we compared the effectiveness, rapidity o...

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Is Valproate Depressogenic in Patients Remitting from Acute Mania? Case Series

Valproate is an effective antimanic agent and is recommended as a first-line medication in the treatment of acute mania. Current evidence based guidelines recommend that valproate should be given as a loading dose as it produces a rapid antimanic and antipsychotic response with minimal side-effects. However, no clear guidelines are available on the appropriate dosing or serum levels of valproat...

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Nowadays, psychiatrists have a wide range of treatment choices to treat acute mania. Introduction of atypical antipsychotics in the last decade has increased the range of available treatments. A good number of double-blind randomized clinical trials have supported the efficacy of several atypicals, (aripiprazole, olanzapine, quetiapine, risperidone, ziprasidone) both as monotherapy and in combi...

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ژورنال

عنوان ژورنال: Cochrane Database of Systematic Reviews

سال: 2019

ISSN: 1465-1858

DOI: 10.1002/14651858.cd004052.pub2